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2 Tumor-associated macrophages: an in-depth analysis The traditional belief that tumor-associated macrophages (TAMs) solely originate from bone marrow monocytic progenitors has evolved substantially in recent years ( 2.1 Diversity and classifications of TAM The diverse origins and functional variability of TAMs ( Figure 2 ) pose considerable difficulties for their ontological classification ( Figure 2 2.2 Macrophage polarization states and their distinctive properties Macrophages exhibit remarkable heterogeneity and adaptability, rapidly responding to environmental cues by polarizing into functionally distinct phenotypes

Hum Mol Genet 29(7):10831095

Crop Sci 40:503510 Liu C, Zhao L, Yu G (2011) The dominant glutamic acid metabolic flux to produce -aminobutyric acid over proline in Nicotiana tabacum leaves under water stress relates to its significant role in antioxidant activity

[2] [3] Taking berberine with food may reduce gastrointestinal side effects

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41