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10.3389/fnmol.2022.937468 52 ChiricostaL.SilvestroS.PizzicannellaJ.DiomedeF.BramantiP.TrubianiO.et al (2019)

Previous reports have revealed that an increase of MDA level was observed in the sputum and serum of COPD patients and correlated well with disease progression (Montao et al., 2010

Seminal studies have demonstrated that nuclear ruptures occur at sites characterized by pronounced curvature [194], leading to DNA damage and genomic instability [188,189,190]

Elevated levels of endogenous oxidative stress may also be related to disease burden, medication regimen, and duration of treatment, age, and excessive physical and emotional stress associated with comorbid medical conditions (34)

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