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Geraniol, a compound in the anthocyanin family, decreases DNA methylation in the NRF2 promoter region of mouse skin epidermal JB6 (JB6 P+) cells and enhances the expression of NRF2 downstream target genes

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This review highlights that key signaling hubs, including TLR/NF-B, JAK/STAT, purinergic P2X7 receptor signaling, heat-shock proteinmediated stress responses, and PI3K/Akt/mTOR pathways, govern the initiation, amplification, and resolution of ischemic AKI

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