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Li RJ, Liu Y, Liu HQ, Li J

The m(6)A methyltransferase METTL3 modifies PGC-1alpha mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes

Fan L, Feng Y, Chen GC, Qin LQ, Fu CL, Chen LH

Wang et al., 2021b

Together, these findings highlight a distinct metabolic signature in ME/CFS, where energy production pathways may fail to respond efficiently to physical exertion, potentially driving exacerbation of symptoms seen in PEM