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doi: 10.1038/s41598-023-28661-6 22 PetersenAHansenLGMirzaNCrocollCMirzaOHalkierBA

These include pharmacokinetic instability related to poor oral bioavailability and rapid metabolism, insufficient tissue-specific delivery to pelvic lesions, limited mechanistic validation in human-relevant 3D organoid and patient-derived xenograft models, a lack of standardized and clinically graded botanical preparations, and a shortage of large-scale randomized controlled trials evaluating efficacy, safety, and long-term outcomes across diverse patient populations