Psoriatic plaques arise due to increased skin cell (keratinocyte) proliferation with incomplete epidermal keratinocyte differentiation and decreased keratinocyte cell death (apoptosis)
Redlich G, Zanger UM, Riedmaier S, Bache N, Giessing AB, Eisenacher M, et al
Glutathione inhibits tyrosinase activity, reducing melanin synthesis and delivering measurable skin brightening, while simultaneously acting as a potent antioxidant that neutralizes reactive oxygen species and supports hepatic detoxification pathways
The rate of loss accelerates during the dose escalation phase and typically peaks around weeks 16-32 when you reach higher maintenance doses
A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism