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doi: 10.1016/j.redox.2024.103411 [DOI] [PMC free article] [PubMed] [Google Scholar] 147.Lin LC, Chang HY, Kuo TT, et al

Elimination is non-linear and dose dependent due to saturation of renal tubular reabsorption, with a half life of 3-10 hrs at low doses & up to 15 hrs at higher doses

Later, this definition was extended to include essentially similar protective effects outside the gastrointestinal tract involving the lesions of different organs (cytoprotection-organoprotection)

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Increased 24 h mean insulin-like growth factor binding protein-3 proteolytic activity in pubertal type 1 diabetic boys