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Huttenlocher PR, de Courten C (1987)

Berberine activates AMP-activated protein kinase (AMPK), influencing glucose metabolism and lipid profiles in metabolic syndrome populations

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This phenotype is driven by the failure of CUL5 to negatively regulate IL-3-induced STAT5 signaling via the CRL5-LRRC41 complex, which is essential for maintaining HSC quiescence and lineage balance

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