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It has different causes

Our analysis relies on modelled estimates of smoking-attributable mortality from GBD 2019, which come with uncertainty intervals (addressed by our upper- and lower-bound sensitivity analysis) and inherently assume that smoking is the primary differentiating factor between the smoker and non-smoker groups

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Sampling and drug analysis Blood samples were drawn after at least 7 days at the target therapeutic dose to keep four elimination half-times and steady state