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The most speculative

Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

A deficiency in vitamin B12 can lead to several symptoms, such as fatigue, weakness, anemia, numbness or tingling in the hands and feet, and cognitive difficulties

Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline