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PMID: 37277863 Adv Sci (Weinh) Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

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After discovering that excessive acid ceramidase drives cell sensitivity to ferroptosis, the researchers removed the enzyme from senescent and non-senescent cells to see whether its absence would make cells more resilient to induced ferroptosis

10.1016/j.jbiotec.2006.03.002