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Cytosolic cysteine is the limiting amino acid for GSH synthesis because it has a low concentration compared to glycine and glutamate

L-Glutathione is also known for its ability to regenerate other antioxidants like Vitamin C and Vitamin E, contributing to overall antioxidant defense

Cells harboring LHON mutations exhibit elevated levels of redox biomarkers such as oxidized GSH and 8-OhdG, coupled with decreased antioxidant activity [[491], [492], [493]]

Since no human clinical trials exist, these numbers are based on animal research and years of community experience