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doi: 10.3389/fimmu.2026.1730351 Received 22 October 2025 Revised 28 January 2026 Accepted 24 February 2026 Published 25 March 2026 Volume 17 - 2026 Edited by Chafia Touil-Boukoffa, University of Science and Technology Houari Boumediene, Algeria Reviewed by Nar Singh Chauhan, Maharshi Dayanand University, India Fatma Naz Cemre Kalayci, DanaFarber Cancer Institute, United States Updates Copyright 2026 Zhan, Wang, Zhan, Yang, Liang, Yu and Wang

The naturally occurring FOXO4 protein appears to regulate the levels of proteasome enzymes, but it does not necessarily help reduce damaged cells

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