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Studies indicate that intracellular calcium overload in AP leads to mitochondrial dysfunction, disrupting ATP synthesis and causing acinar cell damage and necrosis, exacerbating inflammation ( 2 Mitochondria: structure, origin, and the role in cellular function and pathophysiology Mitochondria are crucial organelles in eukaryotic cells, often recognized as the cells powerhouse due to their critical role in energy production

Other organizations differ as to whether they recommend routine screening or case finding in older asymptomatic individuals

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Another approach of TNF- pathway blockade that has been recently examined is the development of orally active small molecules (such as UCB-9260) that destabilize TNF- trimer, impeding TNF--TNFR1 binding and signaling [200]