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Discovery of the first highly selective antagonist of the GluK3 Kainate receptor subtype

doi: 10.1016/j.ijbiomac.2025.147961 325 GanKLiJZhangXFengZLiuJZhaoF

Chemical Information: Molecular Formula: CHO Molecular Weight: 108.14 g/mol CAS Number: 100-51-6 Purity: 99% Product Characteristics: Volume: 30mL Composition: Sterile water containing 0.9% benzyl alcohol Purpose: Solvent/diluent in laboratory research Intended Use: For laboratory research purposes only

The result indicates that the overall pathway is feasible but acetate kinase (AckA) is the limiting step (Figure 4)

However, because hepatotoxicity is a result of complex mechanisms, animal studies must be performed in association with such in vitro experiments