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While antioxidant and anti-inflammatory strategies show considerable promise, several important limitations must be acknowledged

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Eur Respir J 24 : 994999 Balzar S, Chu HW, Strand M, Wenzel S 2005 Relationship of small airway chymase-positive mast cells and lung function in severe asthma

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

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