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Thats why many peptide drugs are delivered subcutaneously (say, through an injector pen or insulin pump) and why it took so long to develop a pill version of semaglutide

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A burning or sharp pain during injection (this may indicate you've hit a blood vessel or muscle) Medication leaking out of the injection site Injection site reactions like bruising, swelling or redness that worsen after the injection Shortness of breath call 911 if this occurs The medication isn't having its intended effects, such as reduced appetite

Six month old young rats were used as controls

The reported effects are consistent across studies: accelerated wound healing, increased tensile strength, faster bone callus formation, and restoration of tissue architecture