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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Extended limitation of Gln or administration of the Gln antagonist 6-diazo-5-oxo-L-norleucine (DON) leads to growth suppression and triggers the ferroptosis pathway in PDAC

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We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable. Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism