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This suggested that the initial compound had likely degraded through hydrolysis to a sulfonic acid derivative 27 with the separate imidazole leaving group present in the mixture, a hypothesis that was confirmed by LC-MS analysis of the original compound stock (Supplementary Fig

Furthermore, TMAO can downregulate intestinal tight junction protein expression, increasing intestinal permeability and establishing a vicious cycle of gut leakage and renal injury (173)

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Choudhry N, Arias IM, Wolkoff AW, Chowdhry JR, Disroders of bilirubin metabolism

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction