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However, while these immunostimulatory effects appear beneficial for individuals with weakened immune systems, they also introduce important safety concerns

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In addition, supplements can be made from animal by-products (for example, bones, hoofs, tendons) and some may contain viruses (for example, mad cow disease) and others have had high concentrations of toxic metals found in the preparation

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Surrogate variables to correct for batch effects To account for potential batch effects , we performed surrogate variable analysis (SVA) based on the DNA methylation levels at all CpG sites located on chromosome 10 using the R/Bioconductor package sva [31]