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Inhibition and induction of UGTs First of all, the fact that most xenobiotic metabolising UGTs show overlapping substrate specificities should be noted

Other serious side effects may include worsening heart failure and kidney problems

Activated caspase-8/10 induces apoptosis through two parallel pathways (Legembre et al., 2002): it either directly cleaves and activates caspase-3 or cleaves the pro-apoptotic Bcl-2 family protein Bid to generate truncated Bid (tBid)

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The identification of these dichotomous astrocytic states, particularly the reparative A2 phenotype, has revealed promising therapeutic targets that will be examined in later sections of this review