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The digestive tract gets caught in an inflammatory storm, which causes symptoms ranging from abdominal pain to severe diarrhea and malnutrition

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Another enzyme, Cytochrome P-450 1B1 (CYP1B1), is involved in the conversion of 17beta-estradiol to 4-hydroxyestradiol, a mutagenic metabolite implicated in breast and endometrial carcinogenesis

219 Immunogenicity Exogenous nucleic acids can be recognized as exogenous signals by pattern recognition receptors in the immune system, triggering immune responses that compromise the structural integrity and stability of the nucleic acids