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Nrf2, a nuclear transcription factor, translocates to the cell nucleus to upregulate HO-1, converting heme to biliverdin, iron, and CO [108]

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While individual responses can vary, most patients report visible improvements within 6-12 weeks of consistent treatment

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Phase 3: Maintenance (Weeks 912) Dose: 23 weekly Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation