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The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] indicating that cysteine may be a limiting substrate for GCL

10.1038/s42003-022-03877-w 67 LizarragaL

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Isaacs, J

Together, these variants can tilt the system toward stronger or prolonged responses to infections or toxins