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J Med Chem 50:22972300

The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration

Using the Wrong Diluent: Using sterile water in a multi-use vial is a serious contamination risk

A similar pattern emerged under oxidative stress: all formulations lowered MCP-1, but inhibition was most pronounced with HA + GSH-C4 (all p 0.001)