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[1] Although water-soluble vitamins are generally excreted through urine when consumed in excess, vitamin B12 is unique in that significant amounts are stored in the liver

That is the bull case for our Second-Order Effects, after all - those materialize most significantly when the penetration in the patient population is highest

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LactMed notes that several studies on its effects on lactation are unable to offer valid conclusions because of their lack of blinding, randomization, and placebo control.48 However, there's at least one randomized control trial of particular relevance here because it used a combination of goat's rue and a silymarin phytosome