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BMJ 1999

It is produced to pharmaceutical-grade specifications including endotoxin testing below 0.25 EU/mL, sterility confirmation by membrane filtration, particulate matter compliance, and pH within the 4.57.0 range ensuring it introduces no contamination into reconstituted research compound solutions

This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur

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