However, high doses may not provide extra benefits and should be avoided
We acknowledge the Elettra-Sincrotrone Trieste (Italy) for support in X-ray data collections and the European Synchrotron Radiation Facility for provision of microscope time on CM01
C (101 MHz, MeOD): 174.48 (C), 172.98 (C), 172.59 (C), 172.27 (C), 171.52 (C), 162.11 (q, J = 35.7 Hz, (C)), 136.28 (d, J = 3.0 Hz, CH), 134.81 (d, J = 10.0 Hz, CH), 131.54 (d, J = 12.6 Hz, CH), 119.94 (d, J = 86.3 Hz, C), 54.01 (CH), 53.51(CH), 41.80 (CH 2 ), 40.09 (CH 2 ), 36.19 (CH 2 ), 35.25 (CH 2 ), 32.36 (CH 2 ), 29.46 (CH 2 ), 28.71 (d, J = 16.8 Hz, CH 2 ), 27.06 (CH 2 ), 23.16 (d, J = 4.3 Hz, CH 2 ), 22.66 (d, J = 51.3 Hz, CH 2 )
Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G
Some PK studies report an increased theoretical risk of toxicity with advancing age [62,63,64,65,66,67] due to prolongation of t 1/2 [62, 63], reduced paracetamol clearance [64, 67], increased paracetamol oxidation caused by a reduction in glucuronidation and sulphation capacity [65] or a reduction in liver volume [66]
