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Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion

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Like most supplements, some users may occasionally experience mild digestive discomfort, loose stools, skin reactions, or headaches, especially when first starting out

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This mechanism is studied in experimental research to investigate proteinprotein interactions and p53-mediated signaling