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In SMMC-7721 cells, GA augmented caspase-3, caspase-9, and ROS production, reducing mitochondrial outer membrane permeabilization (MOMP) production, and eventually causing apoptosis

Non-coding RNA regulation Non-coding RNA regulation refers to the mechanisms by which non-coding RNAs (ncRNAs) modulate gene expression and cellular functions

Sirtuin activity declines proportionally with NAD+ levels, reducing stress resistance and promoting cellular senescence

199 According to postmortem studies, the volume of the dlPFC is smaller and the density of neurons in the dlPFC is lower in MDD

All data were analyzed using SAS 9.2 (SAS Institute, Cary, NC, USA)