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Recent studies, however, have broadened our understanding, revealing their potential roles in producing persulfides and polysulfides ( 2 S is converted to thiosulfate and sulfate (Libiad et al., 2014

However, despite these limitations, the results collectively emphasize the crucial role of Nrf2-mediated oxidative stress in regulating the pathogenesis of RA, providing new insights for the clinical treatment of this condition (Fig

These results supported the hypothesis that ACTL6A impacts GSH de novo synthesis mainly by regulating GCLC expression

Although these dermatological changes are not life-threatening, they frequently contribute to significant psychosocial distress and have been associated with systemic inflammatory activation (70)

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