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We advise that you start on the 3-2-1 protocol for better results

These alterations include biochemical defects, such as impaired control of glutamate metabolism (the major neurotransmitter) [304], as well as the loss of synaptic activity and dendrites [305], apoptosis of neurons primarily in the ganglion cell and inner nuclear layers [306,307], and the activation of microglial cells that may protect the inner retina from injury and contribute to the inflammatory response [308]

The resulting histamine overload causes systemic inflammation, leading to classic MCAS symptoms like sudden hives, flushing, severe gastrointestinal distress, rapid heart rate (tachycardia), and sudden intolerances to previously safe foods

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fibrogen.com [online], (2015)