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In vitro and mechanistic studies (weakest for clinical conclusions) Cell culture studies showing peptides protecting retinal cells from various insults (oxidative stress, glucose toxicity, inflammatory cytokines, hypoxia)
In this cMAK algorithm, the transcriptional, proteomic, and phosphoproteomic data of predicted kinases were wholly considered to reduce potentially false-positive hits, and predicted kinases with differentially regulated mRNAs at 2 time points, changed proteins at 1 time point, or altered phosphorylation sites at 1 time point were retained
For instance, some patients report increased energy as their neurological function improvesthis is a therapeutic effect rather than a true adverse reaction
doi: 10.1186/s13148-023-01469-x 112 AnwayMDLeathersCSkinnerMK