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Besides the initial short-lasting increase of intraocular pressure upon retrobulbar application, which appeared equally upon retrobulbar application of saline, L-NAME, and BPC 157 (Figure 1), intraocular pressure was continuously normal, and it was not otherwise changed upon application of BPC 157 or saline (the data are not specifically shown)

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The peptide's actin-sequestering activity proves particularly important for endothelial cell migration, with studies showing TB-500 significantly enhances endothelial cell migration rates and tube formation in angiogenesis assays while promoting the formation of stable, mature blood vessels with appropriate pericyte coverage