Numerous compounds that activate NRF2 through various mechanisms and structural compositions have been identified ( Pharmacological activation of NRF2: KEAP1-inhibitors Thus far, the most common class of NRF2-activators mimic the inhibition of NRF2s cytoplasmic negative regulator KEAP1, an adaptor protein for the CUL3/RBX1 E3 ubiquitin ligase complex, to prevent NRF2 proteasomal degradation (Kobayashi et al., 2004)
Zhu F, Yan P, Zhang J, Cui Y, Zheng M, Cheng Y, Guo Y, Yang X, Guo X, Zhu H (2019) Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice
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Wiley, London Willekens H, Van Camp W, Van Montagu M, Inze D, Langebartels C, Sandermann H Jr (1994) Ozone, sulfur dioxide, and ultraviolet B have similar effects on mRNA accumulation of antioxidant genes in Nicotiana plumbaginifolia L
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