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Mechanistically, beneficial microbes such as Akkermansia synthesize GABA, which activates the mTOR signaling pathway to promote both M2 macrophage polarization and plasma cell differentiation, sustaining sIgA production and mammary mucosal defense 182

It is sold almost exclusively online as an unregulated "research chemical" labeled "not for human consumption," a designation sellers use to avoid marketing it as an illegal supplement or drug

Long-term studies have not identified significant safety concerns with daily use

It is classified and sold strictly as a laboratory research chemical, intended for use by qualified researchers within controlled research settings

2016;11(10) doi: 10.1371/journal.pone.0152460