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This finding suggests possible non-monotonic dose-response (NMDR) effects, where low-dose exposure may produce different biological responses compared to higher exposure levels ( 4.2.2 Methodological limitations 4.2.2.1 Study design challenges A PCB occupational exposure study involving 89 workers exemplifies common methodological limitations that can obscure true exposure-response relationships

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Slides were dried for at least 20 hours at 4C and fluorescent images were obtained with Slidebook 4.2 Digital Microscopy Software driving an Olympus 1X81 inverted confocal microscope with a 60X oil immersion lens, NA 1.4 and resolution 0.280 Dendritic spine density was measured on primary and secondary dendrites at a distance of at least 150 from the soma

High-dose supplementation can enhance folding and stability of mutant FLAD1, restoring partial enzymatic function via a biochemical flavin chaperone effect (60)