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An increased ROS and MDA levels were observed with a subsequent decrease in thiol levels, CAT, and glutathione-S-transferase activities (129)

Diabetes 50:14641471 Lodge JK, Youn H, Handelman G (1997) Natural sources of lipoic acid: determination of lipoyllysine released from protease-digested tissues by high performance liquid chromatography incorporating electrochemical detection

doi: 10.3389/fendo.2023.1239276

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In preclinical studies, compounds such as VX-765 and pralnacasan have demonstrated efficacy in inhibiting caspase-1 activation and protecting against inflammatory diseases