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In this clinical trial with 20 women, oral supplementation with Pycnogenol was shown to significantly lower UV-induced expression of the pigment synthesizing enzymes TRP1 by 75%, tyrosinase by 51%, MITF by 67% and MART-1 by 67%

Dumbuya H, Alexis A, Lynch S, Callender V, Desai SR, Draelos ZD

Suppression of the malignant phenotype in pancreatic cancer by the overexpression of phospholipid hydroperoxide glutathione peroxidase (PhGPx)

J Physiol Paris (2011) 105:1839.10.1016/j.jphysparis.2011.07.002 182 MilhietVBoudebesseCBellivierFDrouotXHenryCLeboyerMet alCircadian abnormalities as markers of susceptibility in bipolar disorders

Unlike trendy ingredients that arrive with bold claims and minimal evidence, GHK-Cu has decades of peer-reviewed research confirming its ability to stimulate collagen, accelerate tissue repair, reduce inflammation, and measurably improve skin quality