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In each cohort, the doses of cagrilintide and semaglutide were co-escalated in 4-week intervals to the desired dose over 16 weeks

Typically, the initial discomfort dissipates quickly

When to See a Doctor Prompt medical evaluation is warranted if one or more of the following symptoms occur after the injection treatment: Increased pain or swelling at the injection site that progressively worsens Fever, chills, and/or night sweats Uncontrolled or excessive bleeding at the injection site Persistent numbness or weakness in the neck, shoulder, arm, or upper back Headaches Swelling in the arms Before considering a rotator cuff injection, patients are advised to discuss the risks, benefits, and alternative treatments with their doctor.