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The 1x CYP substrate cocktail contained phenacetin (10 M), bupropion (10 M), mephenytoin (50 M), diclofenac (10 M), bufuralol (10 M) and midazolam (5 M)

However, and paradoxically, long-term glutaminolysis activation during nutritional restriction induces an unbalanced activation of mTORC1 during nutrient deprivation and promotes apoptosis [92]

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Symptoms may manifest as muscle weakness, cardiomyopathy, hypoglycemic coma, and abnormal liver function

[DOI] [PubMed] [Google Scholar] 69.Fridhandler TM, Davison JS, Shaffer EA