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Microbial/infection Many specialists have considered IC/PBS to possibly have an infectious origin (bacterial, viral, or fungal) because microorganisms like Helicobacter pylori have been found in association with the condition, which draws parallels to chronic gastritis (Atu et al., 2004

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Mechanistically, JTC801 disrupts lysosomal pH, leading to cholesterol accumulation and activation of SREBF2, a master transcriptional regulator of sterol biosynthesis