First discovered in human plasma in the 1970s, it plays a vital role in signaling tissue remodeling and wound healing
Figure 25
That is why early action matters
Alterations in the secretion and/or sensitivity to GH and IGF-1 may serve as risk factors for the development of several brain diseases or as their correlates
The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)