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Extreme acid or alkaline conditions massively accelerate hydrolysis and should never be used for storage

Negative nitrogen balance occurs when digestion of body protein exceeds synthesis, and results from several circumstances, e.g., too little dietary protein

Store lyophilized at -20C for long-term stability

However, the translational gap between the in vitro efficacy and the in vivo performance of many bioactive compounds (BACs) remains a major bottleneck in the development of efficacious nutraceutical products (1, 2)

Our study provides the mechanistic basis for understanding roGFP2 redox sensing and challenges previous mechanisms for protein disulfide reduction