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Since the drug targets multiple metabolic pathways and has shown impressive early trial outcomes, it is on the news and trials seem to be going in its favour

Nature cell biology, 2023 doi: Fujimaki, K

Tirzepatide is different from semaglutide in that it binds to GLP-1 receptors and glucose-dependent insulinotropic polypeptide (GIP) receptors

Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times