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The cells also become more resistant to lipolysis, the breakdown of stored fat for energy

It is in Phase 3 investigational trials as a "next generation" weight loss medication with potentially fewer side effects compared to single-receptor predecessors like Semaglutide or dual receptor meds like Tirzepatide

Tirzepatide has been associated with modest increases in resting heart rate (mean increase of 24 bpm in clinical trials), though the mechanism is unclear

Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

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