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In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary

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The interplay between GIP and GLP-1 creates synergistic effects that neither pathway achieves alone, which is why tirzepatide results exceeded those of semaglutide in head-to-head comparisons