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However, susceptibility to proteolytic degradation and limited membrane permeability restrict their action to intracellular antioxidant pathways, thereby precluding the systemic immunomodulatory effects observed in other radioprotectants

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Thus, it is also possible that YfeA is not the direct 5OP sensor, but that another protein, upstream in the signaling cascade, binds 5OP

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Thus, the mtDNA copy number in oocytes can reflect their functional status