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However, the anti-oxidation property of the PMI hydrogel was relatively low (5.12%)

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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

Over a 48-hour period, approximately 136 g/cm of copper permeated skin, with an additional 82 g/cm retained in tissue as a depot, suggesting sustained biological activity following application

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