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Dorsomorphin was administered at 4 M concentration from day 3

Traditional methods for identifying compounds and measuring concentrations require significant investment in time, reagents, and trained personnel

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Therefore, CGAS/STING may contribute to ferroptosis in depression, given its involvement in multiple CNS disorders, its capacity to induce ferroptosis in various central and peripheral tissues, and importantly, the observation that its inhibition can effectively alleviate depressive-like behaviors